Title: Oxidative DNA damage is increased in older adults with a major depressive episode: A preliminary study
Authors: Erica L. Vieira, Ana Paula Mendes-Silva, Jessica D. Ferreira, Laiss Bertola, Lucelia Barroso, Monica Vieira, Antonio L. Teixeira, Breno S. Diniz.
In this research article, we demonstrate that:
• DNA oxidation and damage is a possible consequence of elevated oxidative stress in major depressive disorders across the lifespan.
• Participants with LLD have higher levels of 8-oxo-dG indicating more severe DNA oxidative damage.
• Elevated DNA oxidative damage can be a marker of increased activation of age-related biological pathways in LLD.
Contributors
