Thomas Prevot, Ph.D.

Dr. Prevot is a Project Scientist in CAMH, leading the research group focusing on Memory, Emotion, Drugs and Synapses (MEDS), in the Neurobiology of Depression and Aging Department, led by Dr. Etienne Sibille. He is also Assistant Professor of the Department of Psychiatry from the University of Toronto.

Our Research Focus

Dr. Prevot’s research focuses on the neurobiology of memory and emotion processes, and how these processes are affected by stress, aging, and their interactions, leading to psychiatric and neurodegenerative diseases. More specifically, the MEDS team focuses on the characterization of behavioral, cellular and molecular outcomes of preclinical models of depression and other stress- and age-related psychiatric disorders. With expertise in preclinical models, the team has developed a unique expertise in translational research, including the characterization of novel targets for therapeutic avenues and medication development for future clinical testing.
Dr. Prevot is actively involved in the translational research and medicine landscape at the University of Toronto, working across disciplines and being an advocate for bench-to-bedside discovery.

Improve Biomedical Research Awareness with BRAD Global

Biomedical Research Awareness Day (BRAD) is an initiative committed to educating the public on the importance of biomedical research and the humane use of animals. BRAD assists research professionals in their effort to increase awareness around biomedical research at multiple levels. Visit the to learn more, and register to the annual events.

Since September 2020, Dr. Prevot is the Canadian BRAD Champion and contributes to improving awareness on topics revolving around animal research and biomedical development. 

Meet the team

Team Publication List

Yao HK., Guet-McCreight A., Mazza F., Moradi H., Prevot TD., Griffiths J., Tripathy S.J., Valiante T., Sibille E., and Hay E. Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits, Cell Reports, 2022, DOI:

Perez S.M., McCoy A.M., Prevot T.D., Mian M.Y., Carreno F.R., Frazer A., Cook J.M., Sibille E. and Lodge D.J., Hippocampal α5-GABAA receptors modulate dopamine neuron activity in the rat ventral tegmental area, 2022, Biol. Psychiatry Global Open Access;

Grieco F., Bernstein B., et al., Measuring behavior in the home-cage: Study design, applications, challenges and perspectives, Frontiers, 2021, Front. Behav. Neurosci;

Marcotte M, Bernardo A, Linga N, Guillou J-L, Sibille E and Prevot TD. Handling Techniques to Reduce Stress in Mice in 3 Days, JoVE, 202, DOI: 10.3791/62593

Codeluppi S.A., Chatterjee D., Prevot T.D., Misquitta K.A., Sibille E., Banasr M., Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex, Int J Neuropsychopharmacol 2021 Oct 23;24(10):842-853. doi: 10.1093/ijnp/pyab052.

Oh H., Prevot TD, Newton D., and Sibille E., From Serendipity to Rational Drug Design in Brain Disorders: In Silico, In Vitro and In Vivo approaches, Current Opinion in Pharmacol. 2021, DOI: 10.1016/j.coph.2021.07.012

Misquitta K.A., Miles A., Prevot T.D., Knoch J.K., Fee C., Newton D., Ellegood J., Lerch J.P., Sibille E., Nikolova Y., and Banasr M. Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density, NeuroPharm, Epub 2021,; DOI: 10.1016/j.neuropharm.2021.108562

Fee C., Prevot TD., Misquitta KA., Banasr M. and Sibille E. Chronic stress exacerbates acute stress-induced neuronal activation in the anterior cingulate cortex and ventral hippocampus that correlates with behavioral deficits in mice. 2020. BioRXiV. DOI: 10.1101/2020.02.19.956672

Prevot TD., Sumitomo A., Tomoda T., Knutson DE., Li G., Mondal P., Banasr M. and Sibille E. Effect of chronic α5-PAM treatment on cognition and brain morphology in the aging mouse brain, 2020. BioRXiV. DOI: 10.1101/2020.02.28.964742

Prevot TD. and Sibille E. Altered GABA-Mediated Information Processing and Cognitive Dysfunctions in Depression and other Brain Disorders, Mol Psychiatry (2020).

Abela AR., Browne CJ., Sargin D., Prevot TD., Lambe E., Lê, AD and Fletcher PJ. Median raphe serotonin neurons promote anxiety-like behavior via inputs to the dorsal hippocampus, Neuropsychopharm. 2020. DOI:10.1016/j.neuropharm.2020.107985

Prevot TD., Misquitta K, Fee C.J, Newton D, Chatterjee D, Nikolova Y, Sibille E and Banasr M. Residual avoidance: A new, consistent and repeatable readout of chronic stress-induced conflict anxiety reversible by antidepressant treatment. Neuropharmacology. 2019. DOI: 10.1016/j.neuropharm.2019.05.005

Prevot TD., Li G., Cook J.M. and Sibille E. Insight for the treatment of cognitive impairment across disorders, ACS Chemical Neuroscience 2019, DOI: 10.1021/acschemneuro.9b00148

Shukla R, Prevot TD, French L, Isserlin R, Rocco B.R, Banasr M, Bader G, Sibille E. The Relative Contributions of Cell-Dependent Cortical Microcircuit Aging to Cognition and Anxiety. Biological Psychiatry 2019, doi: 10.1016/j.biopsych.2018.09.019

Prevot TD, Guanguan Li, Aleksandra Vidojevic, Anja Santrac, Keith Misquitta, Corey J. Fee, Daniel E. Knutson, Alexander Arnold, Petra Scholze, Janet L. Fisher, Mounira Banasr, Jim Cook, Miroslav Savic and Etienne Sibille, Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles, Molecular Neuropsychiatry 2018, DOI:10.1159/000496086

Nikolova YS, Misquitta KA, Rocco BR, Prevot TD, Knodt AR, Ellegood J, Voineskos AN, Lerch JP, Hariri AR, Sibille E, Banasr M.. Shifting Priorities: Highly conserved behavioral and brain network adaptations to chronic stress across species. Transl Psychiatry. 2018 Jan 22;8(1):26. doi: 10.1038/s41398-017-0083-5. PMID: 29353879


And more on Google Scholar.

Team News Feed






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