Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Human Brain Mapping, October 2020

Authors: Klara Mareckova, Amy Miles, Lenka Andryskova, Milan Brazdil & Yuliya S. Nikolova

Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Here we show that perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex‐specificity of effects. We also demonstrate a link between cortical gyrification and mood disturbance in females. These results highlight the long‐term implications of perinatal stress exposure for cortical morphology and mood dysregulation.